Calcium gluconate

CLINICAL USE

Hypocalcaemia

DOSE IN NORMAL RENAL FUNCTION

Depending on indication

Acute hypocalcaemia:

10 to 20 &nbsp &nbsp : mL calcium gluconate 10% (2.25–4.5 mmol calcium) slow

IV injection over 3–10 minutes

Oral: Dose varies depending on requirements

PHARMACOKINETICS

Molecular weight &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :448.4

%Protein binding &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :–

%Excreted unchanged in urine &nbsp &nbsp : –

Volume of distribution (L/kg) &nbsp &nbsp &nbsp :–

half-life – normal/ESRD (hrs)&nbsp &nbsp &nbsp :–

DOSE IN RENAL IMPAIRMENT

GFR (mL/MIN)

20 to 50 &nbsp &nbsp : Dose as in normal renal function. Titrate to response

10 to 20 &nbsp &nbsp : Dose as in normal renal function. Titrate to response

<10 &nbsp &nbsp &nbsp &nbsp &nbsp : Dose as in normal renal function. Titrate to response

DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES

CAPD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp:Dialysed. Dose as in normal renal function

HD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :Dialysed. Dose as in normal renal function

HDF/high flux &nbsp :Dialysed. Dose as in normal renal function

CAV/VVHD &nbsp &nbsp &nbsp:Dialysed. Dose as in normal renal function

IMPORTANT DRUG INTERACTIONS

Potentially hazardous interactions with other drugs

Can impair absorption of some drugs, e.g. iron, ciprofloxacin

ADMINISTRATION

Reconstition

–

Route

Oral, IV, IM

Rate of Administration

IV: slow 3–4 minutes for each 10 mL (2.25 mmol calcium); not greater than 20 mmol/hour for continuous infusions

Comments

IV: Can be used undiluted for continuous and intermittent infusions

OTHER INFORMATION

Check patient’s magnesium levels

Monitor calcium and PO 4 serum levels

Calcium-Sandoz 400: 10 mmol calcium per tablet

Calcium-Sandoz 1000: 25 mmol calcium per tablet

Calcium levels cannot be corrected until magnesium levels are normal

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