Buspirone hydrochloride.txt Buspirone hydrochloride CLINICAL USE Anxiolytic DOSE IN NORMAL RENAL FUNCTION Initially 5 mg 2–3 times daily. Usual range 15–30 mg daily in divided doses (maximum 45 mg daily) PHARMACOKINETICS Molecular weight                           :422 %Protein binding                           :95 %Excreted unchanged in urine     : 0 Volume of distribution (L/kg)       :2.69–7.91 half-life – normal/ESRD (hrs)      :2–11/Increased by 2 hours1 DOSE IN RENAL IMPAIRMENT GFR (mL/MIN) 20 to 50     : Dose as in normal renal function 10 to 20     : Dose as in normal renal function <10           : Reduce by 25–50% if patient is anuric2 DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES CAPD                :Not dialysed. Dose as in GFR <10 mL/min HD                     :Not dialysed. Dose as in GFR <10 mL/minHDF/high flux   :Unknown dialysability. Dose as in GFR <10 mL/minCAV/VVHD      :Not dialysed. Dose as in normal renal function IMPORTANT DRUG INTERACTIONS Potentially hazardous interactions with other drugs Antibacterials: concentration increased by erythromycin – reduce dose; concentration reduced by rifampicin Antidepressants: risk of severe hypertension with MAOIs – avoid concomitant use Antifungals: concentration increased by itraconazole – reduce dose Antipsychotics: enhanced sedative effects; haloperidol concentration increased Antivirals: concentration increased by ritonavir, increased risk of toxicity Calcium-channel blockers: concentration increased by diltiazem and verapamil – reduce dose Grapefruit juice: concentration increased by grapefruit juice – reduce dose ADMINISTRATION Reconstition – Route Oral Rate of Administration – Comments– OTHER INFORMATION Peak plasma levels occur 60–90 minutes after dosing Steady state plasma concentrations achieved within 2 days, although response to treatment may take 2 weeks Non-sedative Do not use in patients with severe hepatic disease Use in severe renal impairment not recommended; risk of accumulation of active metabolites Tags: post-by-auto-php Continue Reading Previous Previous post: Bleomycin.txtNext Next post: CYCLOTHYMIA.txt Related News sotalol hydrochloride.txt tazocin.txt