Bisacodyl

CLINICAL USE

Laxative

DOSE IN NORMAL RENAL FUNCTION

Oral: 5–10 mg at nightRectal: 10 mg in the morningBowel evacuation:

10 to 20 &nbsp &nbsp : mg orally at night followed by 10 mg as suppositories the next morning

PHARMACOKINETICS

Molecular weight &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :361.4

%Protein binding &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :Negligible

%Excreted unchanged in urine &nbsp &nbsp : 30

Volume of distribution (L/kg) &nbsp &nbsp &nbsp :

half-life – normal/ESRD (hrs)&nbsp &nbsp &nbsp :

DOSE IN RENAL IMPAIRMENT

GFR (mL/MIN)

20 to 50 &nbsp &nbsp : Dose as in normal renal function

10 to 20 &nbsp &nbsp : Dose as in normal renal function

<10 &nbsp &nbsp &nbsp &nbsp &nbsp : Dose as in normal renal function

DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES

CAPD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp:Unknown dialysability. Dose as in normal renal function

HD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :Unknown dialysability. Dose as in normal renal function

HDF/high flux &nbsp :Unknown dialysability. Dose as in normal renal function

CAV/VVHD &nbsp &nbsp &nbsp:Unknown dialysability. Dose as in normal renal function

IMPORTANT DRUG INTERACTIONS

Potentially hazardous interactions with other drugsNone known

ADMINISTRATION

Reconstition

–

Route

Oral, rectal

Rate of Administration

–

Comments

–

OTHER INFORMATION

Absorption is <5% orally or rectally

Rapidly converted in the gut (by intestinal and bacterial enzymes) to its active, but non-absorbed, desacetyl metabolite

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