%Excreted unchanged in urine     : Majority (as unchanged drug and metabolites)
Volume of distribution (L/kg)       :
half-life – normal/ESRD (hrs)      :
DOSE IN RENAL IMPAIRMENT
GFR (mL/MIN)
20 to 50     : Start with low doses and adjust according to response
10 to 20     : Start with low doses and adjust according to response
<10           : Start with low doses and adjust according to response
DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES
CAPD                :Unknown dialysability. Dose as in GFR <10 mL/min
HD                     :Unknown dialysability. Dose as in GFR <10 mL/min
HDF/high flux   :Unknown dialysability. Dose as in GFR <10 mL/min
CAV/VVHD      :Unknown dialysability. Dose as in GFR 10 to 20 mL/min
IMPORTANT DRUG INTERACTIONS
Potentially hazardous interactions with other drugsPhenothiazines and tricyclic anti- depressants: may cause paralytic ileus which can be fatal
ADMINISTRATION
Reconstition
–
Route
IV, IM
Rate of Administration
–
Comments
–
OTHER INFORMATION
Benzatropine pharmacokinetics are not well studied, but the drug apparently is hepatically metabolised to conjugates and may undergo entero-hepatic recycling
Benzatropine has a cumulative effect and a prolonged duration of action; therefore, treatment should commence with the lowest possible dosage and be titrated according to response