ACAMPROSATE CALCIUM.txt ACAMPROSATE CALCIUM CLINICAL USE Maintenance of abstinence in alcohol dependence DOSE IN NORMAL RENAL FUNCTION <60 kg: 666 mg 3 times a day >60 kg: 666 mg at breakfast, 333 mg at midday and 333 mg at night PHARMACOKINETICS Molecular weight                           :400.5 %Protein binding                           :0 %Excreted unchanged in urine     : Majority Volume of distribution (L/kg)       :Approximately 1 half-life – normal/ESRD (hrs)      :33/85.8 DOSE IN RENAL IMPAIRMENT GFR (mL/MIN)30–50 333 mg 3 times daily10–30 333 mg twice daily <10           : 333 mg once daily DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES CAPD                :Dialysed. Dose as in GFR <10 mL/min HD                     :Dialysed. Dose as in GFR <10 mL/min HDF/high flux   :Dialysed. Dose as in GFR <10 mL/min CAV/VVHD      :Dialysed. Dose as in GFR=10–30 mL/min IMPORTANT DRUG INTERACTIONS Potentially hazardous interactions with other drugsNone known ADMINISTRATION Reconstition– Route Oral Rate of Administration –Comments– OTHER INFORMATION Recommended treatment period is a year After a single dose of 666 mg in patients with severe renal impairment, the average maximum concentration was 4 times that in healthy individuals Bioavailability is reduced if administered with food Tags: post-by-auto-php Continue Reading Previous Previous post: ABNORMAL SPINAL CURVATURES.txtNext Next post: Acrivastine.txt Related News sotalol hydrochloride.txt tazocin.txt