CLINICAL USE
Treatment of type 2 diabetes mellitus in combination with other antidiabetic drugs
DOSE IN NORMAL RENAL FUNCTION
With metformin or thiazolidinedione: 50 mg twice daily With a sulphonylurea: 50 mg in the morning
PHARMACOKINETICS
DOSE IN RENAL IMPAIRMENT
GFR (mL/MIN)
DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES
IMPORTANT DRUG INTERACTIONS
Potentially hazardous interactions with other drugs
ADMINISTRATION
Reconstition
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Route
Oral
Rate of Administration
–
Comments
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OTHER INFORMATION
Use is contraindicated in renal impairment due to lack of data Cases of hepatic dysfunction have occasionally been reported The main metabolite (LAY 151) is removed by haemodialysis .
