Vardenafil

CLINICAL USE

Treatment of erectile dysfunction

DOSE IN NORMAL RENAL FUNCTION

5–20 mg approximately 25–60 minutes before sexual activity

PHARMACOKINETICS

Molecular weight : 488.6

%Protein binding : 95

%Excreted unchanged in urine : 2–6

Volume of distribution (L/kg) : 208 litres

half-life – normal/ESRD (hrs) : 4–5

DOSE IN RENAL IMPAIRMENT

GFR (mL/MIN)

Initial doses as for normal renal function, then maintenance doses of: 30–50 Dose as in normal renal function 10–30 Initial dose 5 mg and adjust accordingly

<10 : Initial dose 5 mg and adjust accordingly

DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES

CAPD : Not dialysed. Dose as in GFR <10 mL/min. Use with caution

HD : Not dialysed. Dose as in GFR <10 mL/min. Use with caution

HDF/high flux : Unknown dialysability. Dose as in GFR <10 mL/min. Use with caution

CAV/VVHD : Not dialysed. Dose as in GFR=10–30 mL/min

IMPORTANT DRUG INTERACTIONS

Potentially hazardous interactions with other drugs Alpha-blockers: enhanced hypotensive effect – avoid for 6 hours after alpha- blockers (max dose 5 mg)

Antifungals: concentration increased by ketoconazole, and itraconazole – avoid concomitant use

Antivirals: concentration increased by amprenavir, indinavir, ritonavir, saquinavir – avoid with indinavir and ritonavir; reduce initial dose with saquinavir

Grapefruit juice: concentration possibly increased – avoid concomitant use Nicorandil: possibly enhanced hypotensive effect – avoid concomitant use

Nitrates: possibly enhanced hypotensive effect – avoid concomitant use

ADMINISTRATION

Reconstition

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Route

Oral

Rate of Administration

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Comments

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OTHER INFORMATION

Contraindicated in dialysis patients due to lack of information, therefore suggest use with caution and monitor patients closely .

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