CLINICAL USE

Antifungal agent

DOSE IN NORMAL RENAL FUNCTION

Oral: 100 000–1 000 000 units (1–10 mL) every 6 hoursTopical: Apply 2–4 times daily (depends on formulation)

PHARMACOKINETICS

  • Molecular weight                           :926.1
  • %Protein binding                           :No data
  • %Excreted unchanged in urine     : No data
  • Volume of distribution (L/kg)       :No data
  • half-life – normal/ESRD (hrs)      :No data

    DOSE IN RENAL IMPAIRMENT

    GFR (mL/MIN)

  • 20 to 50     : Dose as in normal renal function
  • 10 to 20     : Dose as in normal renal function
  • <10           : Dose as in normal renal function

    DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES

  • CAPD                :Not dialysed. Dose as in normal renal function
  • HD                     :Not dialysed. Dose as in normal renal function
  • HDF/high flux   :Not dialysed. Dose as in normal renal function
  • CAV/VVHD      :Not dialysed. Dose as in normal renal function

    IMPORTANT DRUG INTERACTIONS

    Potentially hazardous interactions with other drugs

  • None known

    ADMINISTRATION

    Reconstition

    –

    Route

    Oral, topical

    Rate of Administration

    –

    Comments

    –

    OTHER INFORMATION

    Not absorbed from intact skin or mucous membranesNo significant gastrointestinal absorption

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