CLINICAL USE

Antibacterial agent

DOSE IN NORMAL RENAL FUNCTION

400 mg twice daily, duration of course depends on indication

PHARMACOKINETICS

  • Molecular weight                           :319.3
  • %Protein binding                           :14
  • %Excreted unchanged in urine     : 30
  • Volume of distribution (L/kg)       :2.5–3.1
  • half-life – normal/ESRD (hrs)      :3–4/6.5–8

    DOSE IN RENAL IMPAIRMENT

    GFR (mL/MIN)

    30–50 Dose as in normal renal function 10–30 400 mg every 12 to 24 hours

  • <10           : 400 mg daily

    DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES

  • CAPD                :Not dialysed. Dose as in GFR <10 mL/min
  • HD                     :Not dialysed. Dose as in GFR <10 mL/min
  • HDF/high flux   :Unknown dialysability. Dose as in GFR <10 mL/min
  • CAV/VVHD      :Not dialysed. Dose as in GFR=10–30 mL/min

    IMPORTANT DRUG INTERACTIONS

    Potentially hazardous interactions with other drugs

  • Analgesics: increased risk of convulsions with NSAIDs
  • Anticoagulants: anticoagulant effect of coumarins enhanced
  • Antimalarials: manufacturer of artemether with lumefantrine advises avoid concomitant use
  • Ciclosporin: increased risk of nephrotoxicityTheophylline: possibly increased risk of convulsion; increased levels of theophylline

    ADMINISTRATION

    Reconstition

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    Route

    Oral

    Rate of Administration

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    Comments

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