CLINICAL USE

Antibacterial agent

DOSE IN NORMAL RENAL FUNCTION

100 mg twice dailyAcne: 100 mg daily in 1 or 2 divided doses

PHARMACOKINETICS

  • Molecular weight                           :457.5
  • %Protein binding                           :75
  • %Excreted unchanged in urine     : 5–10
  • Volume of distribution (L/kg)       :1–1.5
  • half-life – normal/ESRD (hrs)      :11–26/12–18

    DOSE IN RENAL IMPAIRMENT

    GFR (mL/MIN)

  • 20 to 50     : Dose as in normal renal function
  • 10 to 20     : Dose as in normal renal function
  • <10           : Dose as in normal renal function

    DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES

  • CAPD                :Not dialysed. Dose as in normal renal function
  • HD                     :Not dialysed. Dose as in normal renal function
  • HDF/high flux   :Unknown dialysability. Dose as in normal renal function
  • CAV/VVHD      :Unlikely to be dialysed. Dose as in normal renal function

    IMPORTANT DRUG INTERACTIONS

    Potentially hazardous interactions with other drugs

  • Anticoagulants: possibly enhanced anticoagulant effect of coumarins and phenindione
  • Oestrogens: possibly reduced contraceptive effect of oestrogens (risk probably small)
  • Retinoids: possibly increased risk of benign intracranial hypertension – avoid concomitant use

    ADMINISTRATION

    Reconstition

    –

    Route

    Oral

    Rate of Administration

    –

    Comments

    Do not take iron preparations, indigestion remedies or phosphate binders at the same time of day as minocycline.

    • Tags:

    Related News

    ffddfd

    Hyperlipidemia