Meloxicam – kdc

CLINICAL USE

Cox II inhibitor and analgesic

DOSE IN NORMAL RENAL FUNCTION

7. 5–15 mg daily

PHARMACOKINETICS

Molecular weight :351.4

%Protein binding :99

%Excreted unchanged in urine : 3

Volume of distribution (L/kg) :11 litres

half-life – normal/ESRD (hrs) :20

DOSE IN RENAL IMPAIRMENT

GFR (mL/MIN)

20 to 50 : Dose as in normal renal function

10 to 20 : Dose as in normal renal function, but avoid if possible

<10 : Dose as in normal renal function, but avoid if possible Only use if on dialysis

DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES

CAPD :Not dialysed. Dose as in normal renal function

HD :Not dialysed. Dose as in normal renal function

HDF/high flux :Unlikely to be dialysed. Dose as in normal renal function

CAV/VVHD :Not dialysed. Dose as in GFR 10 to 20 mL/min

IMPORTANT DRUG INTERACTIONS

Potentially hazardous interactions with other drugsACE inhibitors and angiotensin-II antagonists: antagonism of hypotensive effect; increased risk of nephrotoxicity and hyperkalaemia

Analgesics: avoid concomitant use of 2 or more NSAIDs, including aspirin (increased side effects); avoid with ketorolac (increased risk of side effects and haemorrhage)

Antibacterials: possibly increased risk of convulsions with quinolones

Anticoagulants: effects of coumarins enhanced; possibly increased risk of bleeding with heparins and coumarins

Antidepressants: increased risk of bleeding with SSRIs and venlaflaxineAntidiabetic agents: effects of sulphonylureas enhanced

Anti-epileptics: possibly increased phenytoin concentration

Antivirals: increased risk of haematological toxicity with zidovudine; concentration possibly increased by ritonavir

Ciclosporin: may potentiate nephrotoxicity Cytotoxic agents: reduced excretion of methotrexate; increased risk of bleeding with erlotinib

Diuretics: increased risk of nephrotoxicity; antagonism of diuretic effect; hyperkalaemia with potassium-sparing diuretics

Lithium: decreased excretion leading to increased lithium levelsPentoxifylline: possibly increased risk of bleeding

Tacrolimus: possibly increased risk of nephrotoxicity

ADMINISTRATION

Reconstition

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Route

Oral, PR

Rate of Administration

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Comments

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OTHER INFORMATION

Clinical trials have shown renal effects similar to those observed with comparative NSAIDs. Monitor patient for deterioration in renal function and fluid retentionInhibition of renal prostaglandin synthesis by NSAIDs may interfere with renal function, especially in the presence of existing renal disease – avoid if possible; if not, check serum creatinine 48–72 hours after starting NSAID – if raised, discontinue NSAID therapy.Use with caution in renal transplant recipients (can reduce intrarenal autocoid synthesis)Meloxicam should be used with caution in uraemic patients predisposed to gastrointestinal bleeding or uraemic coagulopathiesUse normal doses in patients with CKD 5 on dialysis if they do not pass any urine.

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