Lamivudine
CLINICAL USE
Nucleoside reverse transcriptase inhibitor:Treatment of HIV in combination with other antiretroviral drugsTreatment of chronic hepatitis B in adults
DOSE IN NORMAL RENAL FUNCTION
HIV: 150 mg twice daily or 300 mg dailyHepatitis B: 100 mg daily
PHARMACOKINETICS
DOSE IN RENAL IMPAIRMENT
GFR (mL/MIN)
30–50 HIV: 150 mg daily. Hepatitis B: 100 mg stat then 50 mg daily15–30 HIV: 150 mg stat then 100 mg daily. Hepatitis B: 100 mg stat then 25 mg daily5–15 HIV: 150 mg stat then 50 mg daily. Hepatitis B: 35 mg stat then 15 mg daily<5 HIV: 150 mg stat then 25–50 mg daily.1,2 Hepatitis B: 35 mg stat then 10 mg daily
DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES
IMPORTANT DRUG INTERACTIONS
Potentially hazardous interactions with other drugsTrimethoprim: inhibits excretion of lamivudine – avoid concomitant use of high dose co-trimoxazole
ADMINISTRATION
Reconstition
–
Route
Oral
Rate of Administration
–
Comments
Administer with or without food
OTHER INFORMATION
15 mL of oral suspension contains 3 g of sucroseDosage from Bennett (4th edition): GFR>50 mL/min: 100% of doseGFR=10–50 mL/min: 150 mg loading dose then 50–150 mg dailyGFR <10 mL/min: 50 mg loading dose then 25–50 mg daily