Labetalol hydrochloride
CLINICAL USE
Beta-adrenoceptor blocker:Hypertensive crisis, hypertension
DOSE IN NORMAL RENAL FUNCTION
Oral: 50–800 mg twice daily (in 3–4 divided doses in high doses); maximum 2.4 g daily
IV infusion
: 2 mg/minute until satisfactory response; usual total dose 50–200 mgIV bolus: 50 mg over 1 minute, repeated at 5 minute intervals to a total dose of 200 mgPregnancy: 20–160 mg/hour Hypertension after an MI: 15–120 mg/ hour
PHARMACOKINETICS
DOSE IN RENAL IMPAIRMENT
GFR (mL/MIN)
DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES
IMPORTANT DRUG INTERACTIONS
Potentially hazardous interactions with other drugs
ADMINISTRATION
Reconstition
–
Route
Oral, IV
Rate of Administration
2 mg/minute initially then titrate according to response or to indication
Comments
200 mg labetalol (40 mL) to 200 mL glucose 5%Can be used undiluted. (UK Critical Care Group, Minimum Infusion Volumes for fluid restricted critically ill patients, 3rd Edition, 2006)
OTHER INFORMATION
No adverse effects on renal function No accumulation in renal impairment Hypoglycaemia can occur in dialysis patientsTachyphylaxis can occur with prolonged us