20 to 50     : Dose as in normal renal function15–20 Dose as in normal renal function<15 Dose as in normal renal function. Use with caution
DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES
CAPD                :Unlikely to be dialysed. Dose as in GFR<15 mL/min
HD                     :Unlikely to be dialysed. Dose as in GFR<15 mL/min
HDF/high flux   :Unknown dialysability. Dose as in GFR<15 mL/min
CAV/VVHD      :Unknown dialysability. Dose as in normal renal function
IMPORTANT DRUG INTERACTIONS
Potentially hazardous interactions with other drugs
Anti-arrhythmics: increased risk of ventricular arrhythmias with amiodarone and disopyramide
Antibacterials: concentration possibly increased by clarithromycin and telithromycin – avoid concomitant use; increased risk of ventricular arrhythmias with erythromycin – avoid concomitant use
Antifungals: concentration increased by ketoconazole – avoid concomitant use; concentration increased by fluconazole – reduce initial ivabradine dose; concentration possibly increased by itraconazole – avoid concomitant use
Antimalarials: increased risk of ventricular arrhythmias with mefloquine
Antipsychotics: increased risk of ventricular arrhythmias with pimozide or sertindole
Antivirals: concentration possibly increased by nelfinavir and ritonavir – avoid concomitant use
Beta-blockers: increased risk of ventricular arrhythmias with sotalol
Calcium-channel blockers: concentration increased by diltiazem and verapamil – avoid concomitant use