Ispaghula husk
CLINICAL USE
Bulk-forming laxative
DOSE IN NORMAL RENAL FUNCTION
Fibrelief: 1–6 sachets daily in water in 1–3 divided dosesFybogel: One sachet (3.5 g) in water twice dailyIsogel: 2 teaspoonfuls in water 1–2 times daily (constipation), 3 times daily (diarrhoea)Regulan: 1 sachet in water 1–3 times daily
PHARMACOKINETICS
DOSE IN RENAL IMPAIRMENT
GFR (mL/MIN)
DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES
IMPORTANT DRUG INTERACTIONS
Potentially hazardous interactions with other drugs
ADMINISTRATION
Reconstition
–
Route
Oral
Rate of Administration
–
Comments
Fybogel and regulan should be stirred into 150 mL water and taken as quickly as possible, preferably after mealsAdditional fluid intake should be maintained
OTHER INFORMATION
Fybogel is low in sodium and potassium, containing approximately 0.4 mmol sodium and 0.7 mmol potassium per sachet. It is sugar and gluten free and contains aspartame (contributes to the phenylalanine intake and may affect control of phenylketonuria)Orange and lemon/lime flavours of regulan contain: 3.4 g ispaghula husk BP, 0.23 mmol sodium, <1 mmol potassium per sachet and are gluten and sugar free. They also contain aspartameFibrelief contains aspartame Fluid restrictions in dialysis patients can render these treatments inappropriate