isosorbide mononitrate
CLINICAL USE
Vasodilator:Treatment and prophylaxis of angina Adjunct in congestive heart failure
DOSE IN NORMAL RENAL FUNCTION
20–120 mg/day in divided doses
PHARMACOKINETICS
DOSE IN RENAL IMPAIRMENT
GFR (mL/MIN)
DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES
IMPORTANT DRUG INTERACTIONS
Potentially hazardous interactions with other drugsSildenafil: hypotensive effect significantly enhanced – avoid concomitant useTadalafil: hypotensive effect significantly enhanced – avoid concomitant use
ADMINISTRATION
Reconstition
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Route
Oral
Rate of Administration
–
Comments
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OTHER INFORMATION
Tolerance may develop. This may be minimised by having nitrate-‘free’ periodsisosorbide mononitrate.