Granisetron
CLINICAL USE
Prevention or treatment of nausea and vomiting induced by cytotoxic chemotherapy, radiotherapy, or postoperative nausea and vomiting (PONV)
DOSE IN NORMAL RENAL FUNCTION
Cytotoxic chemotherapy or radiotherapy: PO: 1–2 mg within 1 hour before start —of treatment, then 2 mg daily in 1–2 divided doses during treatmentIV: 3 mg before start of cytotoxic —therapy; up to 2 additional 3 mg doses can be given within 24 hours no less than 10 minutes apartIV Infusion: 40 mcg/kg (max 3 mg) —before treatment; repeated once more if requiredPONV: 1 mg IV before induction of anaesthesia; then 1 mg as required (maximum 2 mg in one day)
PHARMACOKINETICS
DOSE IN RENAL IMPAIRMENT
GFR (mL/MIN)
DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES
IMPORTANT DRUG INTERACTIONS
Potentially hazardous interactions with other drugs
ADMINISTRATION
Reconstition
–
Route
Oral, IV bolus,
IV infusion
Rate of Administration
IV bolus: diluted in 5 mL sodium chloride 0.9% over not less than 30 seconds
IV infusion
:
Comments
Compatible with sodium chloride 0.9%, sodium chloride 0.18% and glucose 4% solution, glucose 5%, Hartmann’s solution, sodium lactate injection, 10% mannitolMaximum administered dose over 24 hours should not exceed 9 mg
OTHER INFORMATION
No special dosing adjustments necessary in patients with renal or hepatic failure.