Flucloxacillin

CLINICAL USE

Antibacterial agent

DOSE IN NORMAL RENAL FUNCTION

Oral: 250–500 mg every 6 hours IV: 250 mg – 2 g every 6 hours IM: 250–500 mg every 6 hours Endocarditis: maximum 2 g every 4 hours if > 85 kgOsteomyelitis: maximum 8 g daily in divided doses

PHARMACOKINETICS

Molecular weight :453.9

%Protein binding :95

%Excreted unchanged in urine : 66–76

Volume of distribution (L/kg) :0.13

half-life – normal/ESRD (hrs) :53–60 minutes/ 135–173 minutes

DOSE IN RENAL IMPAIRMENT

GFR (mL/MIN)

20 to 50 : Dose as in normal renal function

10 to 20 : Dose as in normal renal function

<10 : Dose as in normal renal function up to a total daily dose of 4 g

DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES

CAPD :Not dialysed. Dose as in GFR <10 mL/min

HD :Not dialysed. Dose as in GFR <10 mL/min

HDF/high flux :Not dialysed. Dose as in GFR <10 mL/min

CAV/VVHD :Not dialysed. Dose as in normal renal function

IMPORTANT DRUG INTERACTIONS

Potentially hazardous interactions with other drugsReduces excretion of methotrexate

ADMINISTRATION

Reconstition

IV: 250 mg and 500 mg in 5–10 mL water for injection; 1 g in 15–20 mL water for injectionIM: 250 mg in 1.5 mL water for injection; 500 mg in 2 mL water for injection

Route

IV, IM, oral

Rate of Administration

Bolus: 3–4 minutes Infusion: 30–60 minutes

Comments

Compatible with various infusion fluids

OTHER INFORMATION

Monitor urine for protein at high doses Sodium content of injection: 2.26 mmol/g Monitor liver function tests in hypoalbuminaemic patients receiving high doses of flucloxacillin

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