Fexofenadine hydrochloride

CLINICAL USE

Antihistamine:Symptomatic relief of rhinitis and urticaria

DOSE IN NORMAL RENAL FUNCTION

120–180 mg daily depending on condition

PHARMACOKINETICS

Molecular weight :538.1

%Protein binding :60–70

%Excreted unchanged in urine : 10

Volume of distribution (L/kg) :5–6

half-life – normal/ESRD (hrs) :11–15/19–25

DOSE IN RENAL IMPAIRMENT

GFR (mL/MIN)

20 to 50 : Dose as in normal renal function. Use with care

10 to 20 : Initial dose 60 mg once or twice daily. ‘See Other Information’

<10 : Initial dose 60 mg once daily. See ‘Other Information’

DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES

CAPD :Unlikely dialysability. Dose as in GFR <10 mL/min

HD :Not dialysed. Dose as in GFR <10 mL/min

HDF/high flux :Unknown dialysability. Dose as in GFR <10 mL/min

CAV/VVHD :Unlikely to be dialysed. Dose as in GFR 10 to 20 mL/min

IMPORTANT DRUG INTERACTIONS

Potentially hazardous interactions with other drugsAluminium/magnesium containing antacids: reduced absorption – avoid for 2 hours

ADMINISTRATION

Reconstition

–

Route

Oral

Rate of Administration

–

Comments

Take before food

OTHER INFORMATION

Less than 1.5% of a dose is metabolised via the CP450 3A4 systemLarger doses may be used in patients with renal impairment, but increase carefully as can result in increased sedation

Tags: post-by-auto-php