20 to 50     : Dose as in normal renal function
10 to 20     : Dose as in normal renal function
<10           : Dose as in normal renal function
DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES
CAPD                :Unlikely to be dialysed. Dose as in normal renal function
HD                     :Not dialysed. Dose as in normal renal function
HDF/high flux   :Unlikely to be dialysed. Dose as in normal renal function
CAV/VVHD      :Unlikely to be dialysed. Dose as in normal renal function
IMPORTANT DRUG INTERACTIONS
Potentially hazardous interactions with other drugs
Anticoagulants: effect of coumarins possibly enhanced
Anti-epileptics: effects of phenytoin enhanced
Antivirals: reduced atazanavir concentration – avoid concomitant use
ADMINISTRATION
Reconstition
5 mL sodium chloride 0.9%
Route
Oral, IV
Rate of Administration
Bolus: over 3 minutes Infusion: 10–30 minutes
Comments
Dilute with up to 100 mL sodium chloride 0.9%
OTHER INFORMATION
Can be dispersed in half a glass of non-carbonated water. Stir well until it disintegrates; the liquid with pellets should be drunk immediately or within 30 minutes of preparation. The glass should then be rinsed with water which should also be drunkDo not crush or chew