Dactinomycin
CLINICAL USE
Antineoplastic antibiotic
DOSE IN NORMAL RENAL FUNCTION
Dose varies according to patient tolerance, size and location of neoplasmMaximum dose: 15 mcg/kg or 400–600 mcg/m2 daily for 5 days per 2 week cycle
PHARMACOKINETICS
DOSE IN RENAL IMPAIRMENT
GFR (mL/MIN)
DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES
IMPORTANT DRUG INTERACTIONS
Potentially hazardous interactions with other drugsNone known
ADMINISTRATION
Reconstition
1.1 mL water for injection without preservative
Route
IV
Rate of Administration
15 minutes
Comments
Add to 50 mL glucose 5% or sodium chloride 0.9% (maximum concentration 10 mg/mL) or to a fast running
IV infusion
Avoid direct contact with the skin
OTHER INFORMATION
Nadir for platelet and white cell count usually occurs after 14–21 days, with recovery in 21–25 days15% eliminated by hepatic metabolism. Approximately 30% of the dose was recovered in the urine and faeces in 1 week. Can cause renal abnormalities