Cinnarizine

CLINICAL USE

Vestibular disorders Motion sickness

DOSE IN NORMAL RENAL FUNCTION

Vestibular disorders: 30 mg 3 times a day Motion sickness: 30 mg 2 hours before travel then 15 mg every 8 hours when required

PHARMACOKINETICS

  • Molecular weight                           :368.5
  • %Protein binding                           :80
  • %Excreted unchanged in urine     : <20
  • Volume of distribution (L/kg)       :No data
  • half-life – normal/ESRD (hrs)      :3–6/–

    DOSE IN RENAL IMPAIRMENT

    GFR (mL/MIN)

  • 20 to 50     : Dose as in normal renal function
  • 10 to 20     : Dose as in normal renal function
  • <10           : Dose as in normal renal function

    DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES

  • CAPD                :Unlikely to be dialysed. Dose as in normal renal function
  • HD                     :Unlikely to be dialysed. Dose as in normal renal function
  • HDF/high flux   :Unknown dialysability. Dose as in normal renal function
  • CAV/VVHD      :Unlikely to be dialysed. Dose as in normal renal function

    IMPORTANT DRUG INTERACTIONS

    Potentially hazardous interactions with other drugsNone known

    ADMINISTRATION

    Reconstition

    –

    Route

    Oral

    Rate of Administration

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