Cetirizine hydrochloride

CLINICAL USE

Antihistamine:

  • Symptomatic relief of allergy such as hay fever, urticaria

    DOSE IN NORMAL RENAL FUNCTION

    10 mg daily or 5 mg twice daily

    PHARMACOKINETICS

  • Molecular weight                           :461.8
  • %Protein binding                           :93
  • %Excreted unchanged in urine     : 50–60
  • Volume of distribution (L/kg)       :0.45
  • half-life – normal/ESRD (hrs)      :8–10/20

    DOSE IN RENAL IMPAIRMENT

    GFR (mL/MIN)

  • 20 to 50     : Dose as in normal renal function
  • 10 to 20     : Dose as in normal renal function
  • <10           : 5–10 mg daily

    DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES

  • CAPD                :Unlikely dialysability. Dose as in GFR <10 mL/min
  • HD                     :Not dialysed. Dose as in GFR <10 mL/min
  • HDF/high flux   :Not dialysed. Dose as in GFR <10 mL/min
  • CAV/VVHD      :Unknown dialysability. Dose as in normal renal function

    IMPORTANT DRUG INTERACTIONS

    Potentially hazardous interactions with other drugs

  • None known

    ADMINISTRATION

    Reconstition

    –

    Route

    Oral

    Rate of Administration

    –

    Comments

    Available as tablets and solution

    OTHER INFORMATION

  • Manufacturers recommend halving dose in renal impairment
  • Dose may be titrated up but may result in increased sedation
  • Less than 10% of a dose is removed by haemodialysis
    • Tags:

    Related News

    ffddfd

    Hyperlipidemia