Cefuroxime oral
CLINICAL USE
Antibacterial agent
DOSE IN NORMAL RENAL FUNCTION
125–500 mg every 12 hoursGonorrhoea: single dose of 1 g
PHARMACOKINETICS
DOSE IN RENAL IMPAIRMENT
GFR (mL/MIN)
DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES
IMPORTANT DRUG INTERACTIONS
Potentially hazardous interactions with other drugsAnticoagulants: effects of coumarins may be enhanced
ADMINISTRATION
Reconstition
Route
Oral
Rate of Administration
–
Comments
Take with or after food .134 CEFUroXiME (PArEnTErAL)
CLINICAL USE
Antibacterial agent
DOSE IN NORMAL RENAL FUNCTION
750 mg – 1.5 g every 6–8 hoursMeningitis: 3 g every 8 hours
PHARMACOKINETICS
DOSE IN RENAL IMPAIRMENT
GFR (mL/MIN)
DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES
IMPORTANT DRUG INTERACTIONS
Potentially hazardous interactions with other drugsAnticoagulants: effects of coumarins may be enhanced
ADMINISTRATION
Reconstition
IM: 1 mL of water for injection to each 250 mgIV bolus: 2 mL of water for injection to each 250 mg, but 15 mL of water for injection to 1.5 g
IV infusion
: 1.5 g in 50 mL of water for injection
Route
IM, IV
Rate of Administration
IV bolus: over 3–5 minutes
IV infusion
: over 30 minutes
Comments
Do not mix in syringe with aminoglycoside antibioticsInjection may also be reconstituted with: sodium chloride 0.9%, glucose 5%, glucose saline, Hartmann’s solutionCefuroxime and metronidazole can be mixed (see manufacturer’s guidelines)
OTHER INFORMATION
At high doses, take care in patients receiving concurrent treatment with potent diuretics such as furosemide, or aminoglycosides, as combination can adversely affect renal functionEach 750 mg vial ≡ 1.8 mmol sodiumCefuroxime (parenteral).