Cefaclor

CLINICAL USE

Antibacterial agent

DOSE IN NORMAL RENAL FUNCTION

250 mg every 8 hours (dose may be doubled for more severe infections – maximum 4 g daily)

PHARMACOKINETICS

  • Molecular weight                           :385.8
  • %Protein binding                           :25
  • %Excreted unchanged in urine     : 60–85
  • Volume of distribution (L/kg)       :0.24–0.35
  • half-life – normal/ESRD (hrs)      :0.5–0.9/2.3–2.8

    DOSE IN RENAL IMPAIRMENT

    GFR (mL/MIN)

  • 20 to 50     : Dose as in normal renal function
  • 10 to 20     : Dose as in normal renal function
  • <10           : 250 mg every 8 hours

    DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES

  • CAPD                :Dialysed. 250 mg every 8–12 hours
  • HD                     :Dialysed. 250–500 mg every 8 hours
  • HDF/high flux   :Dialysed. 250–500 mg every 8 hours
  • CAV/VVHD      :Dialysed. Dose as in normal renal function

    IMPORTANT DRUG INTERACTIONS

    Potentially hazardous interactions with other drugs

  • Anticoagulants: effects of coumarins may be enhanced

    ADMINISTRATION

    Reconstition

    –

    Route

    Oral

    Rate of Administration

    –

    Comments

    –

    OTHER INFORMATION

    Cefaclor associated with protracted skin reactions.

    • Tags:

    Related News

    ffddfd

    Hyperlipidemia