DOSE IN RENAL IMPAIRMENT

GFR (mL/MIN)

40–60 400 mg daily15–40 200 mg every 24–48 hours<15 Avoid

DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES

IMPORTANT DRUG INTERACTIONS

Potentially hazardous interactions with other drugsAntibacterials: increased risk of myopathy with daptomycin – try to avoid concomitant useAnticoagulants: enhances effect of coumarins and phenindione; dose of anticoagulant should be reduced by up to 50% and adjusted by monitoring INRAntidiabetics: may improve glucose tolerance and have an additive effect with insulin or sulphonylureasCiclosporin: may increase nephrotoxicity and reduce ciclosporin levelsLipid-regulating drugs: increased risk of myopathy in combination with statins and ezetimibe – avoid with ezetimibe; do not exceed 10 mg of simvastatin1

ADMINISTRATION

Reconstition

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Route

Oral

Rate of Administration

–

Comments

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OTHER INFORMATION

Take dose with or after food Contraindicated in nephrotic syndrome There should be an interval of 2 hours between intake of ion exchange resin and bezafibrateModified-release preparation is not appropriate in renal impairment