ACAMPROSATE CALCIUM

CLINICAL USE

Maintenance of abstinence in alcohol dependence

DOSE IN NORMAL RENAL FUNCTION

<60 kg: 666 mg 3 times a day

>60 kg: 666 mg at breakfast, 333 mg at midday and 333 mg at night

PHARMACOKINETICS

Molecular weight :400.5

%Protein binding :0

%Excreted unchanged in urine : Majority

Volume of distribution (L/kg) :Approximately 1

half-life – normal/ESRD (hrs) :33/85.8

DOSE IN RENAL IMPAIRMENT

GFR (mL/MIN)

30–50 333 mg 3 times daily10–30 333 mg twice daily

<10 : 333 mg once daily

DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES

CAPD :Dialysed. Dose as in GFR <10 mL/min

HD :Dialysed. Dose as in GFR <10 mL/min

HDF/high flux :Dialysed. Dose as in GFR <10 mL/min

CAV/VVHD :Dialysed. Dose as in GFR=10–30 mL/min

IMPORTANT DRUG INTERACTIONS

Potentially hazardous interactions with other drugsNone known

ADMINISTRATION

Reconstition

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Route

Oral

Rate of Administration

–

Comments

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OTHER INFORMATION

Recommended treatment period is a year

After a single dose of 666 mg in patients with severe renal impairment, the average maximum concentration was 4 times that in healthy individuals

Bioavailability is reduced if administered with food

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