ACAMPROSATE CALCIUM

CLINICAL USE

Maintenance of abstinence in alcohol dependence

DOSE IN NORMAL RENAL FUNCTION

  • <60 kg: 666 mg 3 times a day
  • >60 kg: 666 mg at breakfast, 333 mg at midday and 333 mg at night

    PHARMACOKINETICS

  • Molecular weight                           :400.5
  • %Protein binding                           :0
  • %Excreted unchanged in urine     : Majority
  • Volume of distribution (L/kg)       :Approximately 1
  • half-life – normal/ESRD (hrs)      :33/85.8

    DOSE IN RENAL IMPAIRMENT

    GFR (mL/MIN)

    30–50 333 mg 3 times daily10–30 333 mg twice daily

  • <10           : 333 mg once daily

    DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES

  • CAPD                :Dialysed. Dose as in GFR <10 mL/min
  • HD                     :Dialysed. Dose as in GFR <10 mL/min
  • HDF/high flux   :Dialysed. Dose as in GFR <10 mL/min
  • CAV/VVHD      :Dialysed. Dose as in GFR=10–30 mL/min

    IMPORTANT DRUG INTERACTIONS

    Potentially hazardous interactions with other drugsNone known

    ADMINISTRATION

    Reconstition

    Route

    Oral

    Rate of Administration

    Comments

    OTHER INFORMATION

  • Recommended treatment period is a year
  • After a single dose of 666 mg in patients with severe renal impairment, the average maximum concentration was 4 times that in healthy individuals
  • Bioavailability is reduced if administered with food
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