{"id":967,"date":"2023-01-13T11:16:51","date_gmt":"2023-01-13T11:16:51","guid":{"rendered":"https:\/\/kidneydiseaseclinic.net\/blog\/?p=967"},"modified":"2023-01-13T11:16:51","modified_gmt":"2023-01-13T11:16:51","slug":"cefixime","status":"publish","type":"post","link":"https:\/\/kidneydiseaseclinic.net\/blog\/cefixime\/","title":{"rendered":"Cefixime"},"content":{"rendered":"\n<h2 class=\"wp-block-heading\">DESCRIPTION<\/h2>\n\n\n\n<p>Cefixime -Cefixime, an antibiotic, is a third-generation cephalosporin like ceftriaxone and cefotaxime. Cefixime is highly stable in the presence of beta-lactamase enzymes. As a result, many organisms resistant to penicillins and some cephalosporins due to the presence of beta-lactamases, may be susceptible to cefixime. The antibacterial effect of cefixime results from inhibition of mucopeptide synthesis in the bacterial cell wall. Ornidazole &#8211; Ornidazole is a drug that cures some protozoan infections.,It has been investigated for use in Crohn&#8217;s disease after bowel resection.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">CATEGORIES<\/h2>\n\n\n\n<p>Cefixime &#8211; Anti-Bacterial Agents , Cephalosporins .Ornidazole &#8211; Antiamoebics .<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">CHEMICAL FORMULA<\/h2>\n\n\n\n<p>Cefixime &#8211; C16H15N5O7S2 . Ornidazole &#8211; C7H10ClN3O3 .<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">COMPOSITION<\/h2>\n\n\n\n<p>Cefixime 200mg + Ornidazole 500mg<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">INDICATION<\/h2>\n\n\n\n<p>Cefixime &#8211; For use in the treatment of the following infections when caused by susceptible strains of the designated microorganisms: (1) uncomplicated urinary tract infections caused by Escherichia coli and Proteus mirabilis, (2) otitis media caused by Haemophilus influenzae (beta-lactamase positive and negative strains), Moraxella catarrhalis (most of which are beta-lactamase positive), and S. pyogenes, (3) pharyngitis and tonsillitis caused by S. pyogenes, (4) acute bronchitis and acute exacerbations of chronic bronchitis caused by Streptococcus pneumoniae and Haemophilus influenzae (beta-lactamase positive and negative strains), and (5) uncomplicated gonorrhea (cervical\/urethral) caused by Neisseria gonorrhoeae (penicillinase- and non-penicillinase-producing strains). Ornidazole &#8211; This medication is an antiamoebic agent, prescribed for amoebic dysentery.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">PHARMACODYNAMICS<\/h2>\n\n\n\n<p>Cefixime &#8211; Cefixime, an antibiotic, is a third-generation cephalosporin like ceftriaxone and cefotaxime. Cefixime is highly stable in the presence of beta-lactamase enzymes. As a result, many organisms resistant to penicillins and some cephalosporins due to the presence of beta-lactamases, may be susceptible to cefixime. The antibacterial effect of cefixime results from inhibition of mucopeptide synthesis in the bacterial cell wall.<\/p>\n\n\n\n<p>No Information<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">ABSORPTION<\/h2>\n\n\n\n<p>Cefixime &#8211; About 40%-50% absorbed orally whether administered with or without food, however, time to maximal absorption is increased approximately 0.8 hours when administered with food.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">METABOLISM<\/h2>\n\n\n\n<p>Cefixime &#8211; Hepatic. Approximately 50% of the absorbed dose is excreted unchanged in the urine in 24 hours. Ornidazole -Metabolised via the liver, excreted in the Urine and Feces<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">ELIMINATION<\/h2>\n\n\n\n<p>Ornidazole &#8211; 85% of single oral dose is eliminated with 5 days &#8211; Urine (63%) and Feces (22%)<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">HALF LIFE<\/h2>\n\n\n\n<p>Cefixime -3-4 hours (may range up to 9 hours). In severe renal impairment (5 to 20 mL\/min creatinine clearance), the half-life increased to an average of 11.5 hours.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">TOXICITY<\/h2>\n\n\n\n<p>Cefixime &#8211; Symptoms of overdose include blood in the urine, diarrhea, nausea, upper abdominal pain, and vomiting.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">FOOD INTERACTIONS<\/h2>\n\n\n\n<p>avoid alcohol<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">SIDE EFFECTS<\/h2>\n\n\n\n<p>Cefixime &#8211; Upset stomach or throwing up. Many small meals, good mouth care, sucking hard, sugar-free candy, or chewing sugar-free gum may help. &#8211; Loose stools (diarrhea). Yogurt or probiotics may help. You may get these products at health food stores or in some pharmacies. &#8211; For women, vaginal yeast infection. Report itching or discharge. Ornidazole -Nausea, pain the abdomen, vertigo, headache, skin rash are generally reported. Somnolence, headache, vomiting, dizziness, tremor, rigidity, poor coordination, tiredness, vertigo, mixed peripheral neuropathy, taste disturbances, abnormal LFTs, skin reactions.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>DESCRIPTION Cefixime -Cefixime, an antibiotic, is a third-generation cephalosporin like ceftriaxone and cefotaxime. Cefixime is highly stable in the presence of beta-lactamase enzymes. As a result, many organisms resistant to penicillins and some cephalosporins due to the presence of beta-lactamases, may be susceptible to cefixime. The antibacterial effect of cefixime results from inhibition of mucopeptide [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-967","post","type-post","status-publish","format-standard","hentry","category-med"],"_links":{"self":[{"href":"https:\/\/kidneydiseaseclinic.net\/blog\/wp-json\/wp\/v2\/posts\/967","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/kidneydiseaseclinic.net\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/kidneydiseaseclinic.net\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/blog\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/blog\/wp-json\/wp\/v2\/comments?post=967"}],"version-history":[{"count":1,"href":"https:\/\/kidneydiseaseclinic.net\/blog\/wp-json\/wp\/v2\/posts\/967\/revisions"}],"predecessor-version":[{"id":968,"href":"https:\/\/kidneydiseaseclinic.net\/blog\/wp-json\/wp\/v2\/posts\/967\/revisions\/968"}],"wp:attachment":[{"href":"https:\/\/kidneydiseaseclinic.net\/blog\/wp-json\/wp\/v2\/media?parent=967"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/blog\/wp-json\/wp\/v2\/categories?post=967"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/blog\/wp-json\/wp\/v2\/tags?post=967"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}