{"id":953,"date":"2023-01-13T11:10:01","date_gmt":"2023-01-13T11:10:01","guid":{"rendered":"https:\/\/kidneydiseaseclinic.net\/blog\/?p=953"},"modified":"2023-01-13T11:10:02","modified_gmt":"2023-01-13T11:10:02","slug":"piroxicam","status":"publish","type":"post","link":"https:\/\/kidneydiseaseclinic.net\/blog\/piroxicam\/","title":{"rendered":"piroxicam"},"content":{"rendered":"\n<h2 class=\"wp-block-heading\">DESCRIPTION<\/h2>\n\n\n\n<p>A cyclooxygenase inhibiting, non-steroidal anti-inflammatory agent (NSAID) that is well established in treating rheumatoid arthritis and osteoarthritis and used for musculoskeletal disorders, dysmenorrhea, and postoperative pain. Its long half-life enables it to be administered once daily.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">CATEGORIES<\/h2>\n\n\n\n<p>Anti-Inflammatory Agents, Non-Steroidal,Cyclooxygenase Inhibitors.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">CHEMICAL FORMULA<\/h2>\n\n\n\n<p>C15H13N3O4S<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">COMPOSITION<\/h2>\n\n\n\n<p>piroxicam Dispersible tab 20 mg<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">INDICATION<\/h2>\n\n\n\n<p>For treatment of osteoarthritis and rheumatoid arthritis.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">PHARMACODYNAMICS<\/h2>\n\n\n\n<p>Piroxicam is in a class of drugs called nonsteroidal anti-inflammatory drugs (NSAIDs). Piroxicam works by reducing hormones that cause inflammation and pain in the body. Piroxicam is used to reduce the pain, inflammation, and stiffness caused by rheumatoid arthritis and osteoarthritis.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">MECHANISM<\/h2>\n\n\n\n<p>The antiinflammatory effect of Piroxicam may result from the reversible inhibition of cyclooxygenase, causing the peripheral inhibition of prostaglandin synthesis. The prostaglandins are produced by an enzyme called Cox-1. Piroxicam blocks the Cox-1 enzyme, resulting into the disruption of production of prostaglandins. Piroxicam also inhibits the migration of leukocytes into sites of inflammation and prevents the formation of thromboxane A2, an aggregating agent, by the platelets.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">ABSORPTION<\/h2>\n\n\n\n<p>Well absorbed following oral administration.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">VOLUME DISTRIBUTION<\/h2>\n\n\n\n<p>0.14 L\/kg<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">METABOLISM<\/h2>\n\n\n\n<p>Renal<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">ELIMINATION<\/h2>\n\n\n\n<p>Piroxicam and its biotransformation products are excreted in urine and feces, with about twice as much appearing in the urine as in the feces. Approximately 5% of a piroxicam dose is excreted unchanged. However, a substantial portion of piroxicam elimination occurs by hepatic metabolism. Piroxicam is excreted into human milk.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">HALF LIFE<\/h2>\n\n\n\n<p>30 to 86 hours<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">TOXICITY<\/h2>\n\n\n\n<p>mptoms of overdose include drowsiness, nausea, stomach pain, and\/or vomiting.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">FOOD INTERACTIONS<\/h2>\n\n\n\n<p>avoid alcohol<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">SIDE EFFECTS<\/h2>\n\n\n\n<p>Feeling dizzy. Rise slowly over a few minutes when sitting or lying down. Be careful climbing. Belly pain or heartburn. Upset stomach or throwing up. Many small meals, good mouth care, sucking hard, sugar-free candy, or chewing sugar-free gum may help.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>DESCRIPTION A cyclooxygenase inhibiting, non-steroidal anti-inflammatory agent (NSAID) that is well established in treating rheumatoid arthritis and osteoarthritis and used for musculoskeletal disorders, dysmenorrhea, and postoperative pain. Its long half-life enables it to be administered once daily. CATEGORIES Anti-Inflammatory Agents, Non-Steroidal,Cyclooxygenase Inhibitors. CHEMICAL FORMULA C15H13N3O4S COMPOSITION piroxicam Dispersible tab 20 mg INDICATION For treatment of [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-953","post","type-post","status-publish","format-standard","hentry","category-med"],"_links":{"self":[{"href":"https:\/\/kidneydiseaseclinic.net\/blog\/wp-json\/wp\/v2\/posts\/953","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/kidneydiseaseclinic.net\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/kidneydiseaseclinic.net\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/blog\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/blog\/wp-json\/wp\/v2\/comments?post=953"}],"version-history":[{"count":1,"href":"https:\/\/kidneydiseaseclinic.net\/blog\/wp-json\/wp\/v2\/posts\/953\/revisions"}],"predecessor-version":[{"id":954,"href":"https:\/\/kidneydiseaseclinic.net\/blog\/wp-json\/wp\/v2\/posts\/953\/revisions\/954"}],"wp:attachment":[{"href":"https:\/\/kidneydiseaseclinic.net\/blog\/wp-json\/wp\/v2\/media?parent=953"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/blog\/wp-json\/wp\/v2\/categories?post=953"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/blog\/wp-json\/wp\/v2\/tags?post=953"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}