ACE inhibitors block ACE in the lungs from converting angiotensin I, activated when renin is released from the kidneys, to angiotensin II, a powerful vasoconstrictor. Blocking this conversion leads to decreased BP, decreased aldosterone secretion, a small increase in serum potassium levels, and sodium and fluid loss; increased prostaglandin synthesis also may be involved in the antihypertensive action.<\/p>\n\n\n\n
Treatment of hypertension (alone or with thiazide type diuretics)<\/p>\n\n\n\n
Treatment of heart failure (used with diuretics and digitalis)<\/p>\n\n\n\n
Treatment of stable patients within 24 hr of acute MI to improve survival (lisinopril)Reduction in risk of MI, stroke, and death from CV causes (ramipril)<\/p>\n\n\n\n
Treatment of left ventricular dysfunction post-MI (captopril, trandolapril)<\/p>\n\n\n\n
Treatment of asymptomatic left ventricular dysfunction (enalapril)<\/p>\n\n\n\n
Treatment of diabetic nephropathy (captopril)Unlabeled uses: <\/p>\n\n\n\n
Renovascular hypertension, nondiabetic nephropathy, migraine prophylaxis, stroke prevention, heart failure, high risk of CAD, diabetes, chronic renal disease, scleroderma renal crisis<\/p>\n\n\n\n
Contraindicated with allergy to the drug, <\/p>\n\n\n\n
impaired renal function, heart failure, salt or volume depletion, lactation, pregnancy, history of angioedema, bilateral renal artery stenosis.<\/p>\n\n\n\n
CNS: Dizziness, headache, fatigue<\/p>\n\n\n\n
CV: Tachycardia, angina pectoris, MI, Raynauds syndrome, heart failure, hypotension in salt or volume depleted patients<\/p>\n\n\n\n
Dermatologic: Rash,pruritus, alopecia, pemphigoid like reaction, scalded mouth sensation, exfoliative dermatitis, photosensitivity<\/p>\n\n\n\n
GI: Gastric irritation, aphthous ulcers,peptic ulcers, dysgeusia, cholestatic jaundice, hepatocellular injury, anorexia, constipation<\/p>\n\n\n\n
GU: Proteinuria, renal insufficiency, renal failure,polyuria, oliguria, urinary frequency<\/p>\n\n\n\n
Hematologic: Neutropenia, agranulocytosis, thrombocytopenia, hemolytic anemia, pancytopenia, hyperkalemia<\/p>\n\n\n\n
Other: Cough,malaise, dry mouth, lymph- adenopathy, angioedema<\/p>\n\n\n\n
Drug-drug<\/p>\n\n\n\n
Increased risk of hypersensitivity reactions with allopurinol<\/p>\n\n\n\n
Decreased anti- hypertensive effects with indomethacin<\/p>\n\n\n\n
Increased risk of hyperkalemia if combined with aldosterone blockers, potassium-sparing diuretics, aliskiren, cyclosporine, potassium supplements<\/p>\n\n\n\n
Decreased absorption of selected drugs if taken with food<\/p>\n\n\n\n False positive test for urine acetone<\/p>\n","protected":false},"excerpt":{"rendered":" ACE inhibitors block ACE in the lungs from converting angiotensin I, activated when renin is released from the kidneys, to angiotensin II, a powerful vasoconstrictor. Blocking this conversion leads to decreased BP, decreased aldosterone secretion, a small increase in serum potassium levels, and sodium and fluid loss; increased prostaglandin synthesis also may be involved in […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-660","post","type-post","status-publish","format-standard","hentry","category-med"],"_links":{"self":[{"href":"https:\/\/kidneydiseaseclinic.net\/blog\/wp-json\/wp\/v2\/posts\/660","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/kidneydiseaseclinic.net\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/kidneydiseaseclinic.net\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/blog\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/blog\/wp-json\/wp\/v2\/comments?post=660"}],"version-history":[{"count":1,"href":"https:\/\/kidneydiseaseclinic.net\/blog\/wp-json\/wp\/v2\/posts\/660\/revisions"}],"predecessor-version":[{"id":661,"href":"https:\/\/kidneydiseaseclinic.net\/blog\/wp-json\/wp\/v2\/posts\/660\/revisions\/661"}],"wp:attachment":[{"href":"https:\/\/kidneydiseaseclinic.net\/blog\/wp-json\/wp\/v2\/media?parent=660"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/blog\/wp-json\/wp\/v2\/categories?post=660"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/blog\/wp-json\/wp\/v2\/tags?post=660"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
Drug-food<\/strong><\/p>\n\n\n\n
Drug-lab test<\/strong><\/p>\n\n\n\n