USP-NF: Acetyltriethyl Citrate<\/p>\n\n\n\n
ATEC; Citroflex A-2; triethyl acetylcitrate; triethyl O-acetylcitrate; triethyl citrate acetate.<\/p>\n\n\n\n
1,2,3-Propanetricarboxylic acid, 2-acetyloxy, triethyl ester [77-894]<\/p>\n\n\n\n
C14H22O8 318.3<\/p>\n\n\n\n
Plasticizer.<\/p>\n\n\n\n
Technology Acetyltriethyl citrate is used to plasticize polymers in formulated pharmaceutical coatings.(1) The coating applications include capsules, tablets, beads and granules for taste masking, immediate release, sustained-release and enteric formulations.(2\u20135) It is also used in diffusion-controlled release drug delivery systems.(6)<\/p>\n\n\n\n
Acetyltriethyl citrate occurs as a clear, odorless, practically colorless oily liquid.<\/p>\n\n\n\n
See Table I. Table I: Pharmacopeial specifications for acetyltriethyl citrate. Test USP32\u2013NF27 Identification Specific gravity \u00fe1.135\u20131.139 Refractive index 1.432\u20131.441 Acidity Water \u00fe40.3% Heavy metals 40.001% Assay (anhydrous basis) 599.0%<\/p>\n\n\n\n
Acid value 0.02 Boiling point 2948C (decomposes) Flash point 1888C Pour point 438C Solubility Soluble 1 in 140 of water; miscible with acetone, ethanol, and propan-2-ol. Viscosity (dynamic) 54mPas (54cP) at 258C.<\/p>\n\n\n\n
Acetyltriethyl citrate should be stored in dry, closed containers at temperatures not exceeding 388C. When stored in accordance with these conditions, acetyltriethyl citrate is a stable product.<\/p>\n\n\n\n
Acetyltriethyl citrate is incompatible with strong alkalis and oxidizing materials.<\/p>\n\n\n\n
Acetyltriethyl citrate is prepared by the esterification of citric acid with ethanol followed by acylation with acetic anhydride.<\/p>\n\n\n\n
Acetyltriethyl citrate is used in oral pharmaceutical formulations and is generally regarded as a nontoxic and nonirritating material. However, ingestion of large quantities may be harmful. LD50 (cat, oral): 8.5g\/kg(7) LD50 (mouse, IP): 1.15g\/kg LD50 (rat, oral): 7g\/kg<\/p>\n\n\n\n
Observe normal precautions appropriate to the circumstances and quantity of material handled. Acetyltriethyl citrate may be irritating to the eyes or the respiratory system as a mist or at elevated temperatures. Gloves and eye protection are recommended for normal handling and a respirator is recommended if used at elevated temperatures.<\/p>\n\n\n\n
Approved in the USA for direct food contact in food films. 17 Related Substances Acetyltributyl citrate; tributyl citrate; triethyl citrate.<\/p>\n\n\n\n
The EINECS number for acetyltriethyl citrate is 201-066-5. The 10 PubChem Compound ID (CID) for acetyltriethyl citrate is 6504. 19 Specific References 1 Jensen JL et al. Variables that affect the mechanism of drug release from osmotic pumps coated with acrylate\/methacrylate copolymer latexes. J Pharm Sci 1995; 84: 530\u2013533. 2 Gutierrez-Rocca JC, McGinity JW. Influence of water soluble and insoluble plasticizer on the physical and mechanical properties of acrylic resin copolymers. Int J Pharm 1994; 103: 293\u2013301. 3 Lehmann K. Chemistry and application properties of polymethacrylate coating systems. McGinity JW, ed. Aqueous Polymeric Coatings for Adipic Acid 11 4 5 6 7 Pharmaceutical Dosage Forms. New York: Marcel Dekker, 1989; 153\u2013 245. Steurnagel CR. Latex emulsions for controlled drug delivery. McGinity JW, ed. Aqueous Polymeric Coatings for Pharmaceutical Dosage Forms. New York: Marcel Dekker,1\u201361. Gutierrez-Rocca JC, McGinity JW. Influence of aging on the physicalmechanical properties of acrylic resin films cast from aqueous dispersions and organic solutions. Drug Dev Ind Pharm 1993; 19(3): 315\u2013332. Siepmann J et al. Diffusion-controlled drug delivery systems: calculation of the required composition to achieve desired release profiles. J Control Release 1999; 60(2\u20133): 379\u2013389. Lewis RJ, ed. Sax\u2019s Dangerous Properties of Industrial Materials, 11th edn. New York: Wiley, 2004; 58\u201359.<\/p>\n\n\n\n
\u2014<\/p>\n\n\n\n
s ME Quinn, PJ Sheskey.<\/p>\n\n\n\n
18 February 2009.<\/p>\n","protected":false},"excerpt":{"rendered":"
Nonproprietary Names USP-NF: Acetyltriethyl Citrate Synonyms ATEC; Citroflex A-2; triethyl acetylcitrate; triethyl O-acetylcitrate; triethyl citrate acetate. Chemical Name and CAS Registry Number 1,2,3-Propanetricarboxylic acid, 2-acetyloxy, triethyl ester [77-894] Empirical Formula and Molecular Weight C14H22O8 318.3 Structural Formula Functional Category Plasticizer. Applications in Pharmaceutical Formulation or Technology Technology Acetyltriethyl citrate is used to plasticize polymers in […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-1318","post","type-post","status-publish","format-standard","hentry","category-med"],"_links":{"self":[{"href":"https:\/\/kidneydiseaseclinic.net\/blog\/wp-json\/wp\/v2\/posts\/1318","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/kidneydiseaseclinic.net\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/kidneydiseaseclinic.net\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/blog\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/blog\/wp-json\/wp\/v2\/comments?post=1318"}],"version-history":[{"count":1,"href":"https:\/\/kidneydiseaseclinic.net\/blog\/wp-json\/wp\/v2\/posts\/1318\/revisions"}],"predecessor-version":[{"id":1319,"href":"https:\/\/kidneydiseaseclinic.net\/blog\/wp-json\/wp\/v2\/posts\/1318\/revisions\/1319"}],"wp:attachment":[{"href":"https:\/\/kidneydiseaseclinic.net\/blog\/wp-json\/wp\/v2\/media?parent=1318"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/blog\/wp-json\/wp\/v2\/categories?post=1318"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/blog\/wp-json\/wp\/v2\/tags?post=1318"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}