Nimesulide is a relatively COX-2 selective, non-steroidal anti-inflammatory drug (NSAID) with analgesic and antipyretic properties. Its approved indications are the treatment of acute pain, the symptomatic treatment of osteoarthritis and primary dysmenorrhoea in adolescents and adults above 12 years old. Due to concerns about the risk of hepatotoxicity, nimesulide has been withdrawn from market in many countries.<\/p>\n\n\n\n
Anti-Inflammatory Agents, Non-Steroidal<\/p>\n\n\n\n
C13H12N2O5S<\/p>\n\n\n\n
Nimesulide 100 MG<\/p>\n\n\n\n
For the treatment of acute pain, the symptomatic treatment of osteoarthritis and primary dysmenorrhoea in adolescents and adults above 12 years old.<\/p>\n\n\n\n
Food, gender and advanced age have negligible effects on nimesulide pharmacokinetics.<\/p>\n\n\n\n
The therapeutic effects of Nimesulide are the result of its complete mode of action which targets a number of key mediators of the inflammatory process such as: COX-2 mediated prostaglandins, free radicals, proteolytic enzymes and histamine.<\/p>\n\n\n\n
Rapidly absorbed following oral administration.<\/p>\n\n\n\n
Hepatic. Extensive biotransformation, mainly to 4-hydroxynimesulide (which also appears to be biologically active).<\/p>\n\n\n\n
Renal (50%), fecal (29%)<\/p>\n\n\n\n
1.8\u20134.7 hours<\/p>\n\n\n\n
Oral TDLO (human): 1.429 mg\/kg; Oral TDLO (woman): 2 mg\/kg; Oral LD50 (rat): 200 mg\/kg; Oral LD50 (mouse): 392 mg\/kg<\/p>\n\n\n\n
avoid alcohol<\/p>\n\n\n\n
Nimesulide may cause dizziness. If you feel dizzy, do not drive or take part in any activity in which you need to be alert. Nimesulide is likely to cause stomach discomfort such as nausea, diarrhoea and stomach pain. Be sure to take it with food. This will help minimise the stomach discomfort.<\/p>\n","protected":false},"excerpt":{"rendered":"
DESCRIPTION Nimesulide is a relatively COX-2 selective, non-steroidal anti-inflammatory drug (NSAID) with analgesic and antipyretic properties. Its approved indications are the treatment of acute pain, the symptomatic treatment of osteoarthritis and primary dysmenorrhoea in adolescents and adults above 12 years old. Due to concerns about the risk of hepatotoxicity, nimesulide has been withdrawn from market […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-1087","post","type-post","status-publish","format-standard","hentry","category-med"],"_links":{"self":[{"href":"https:\/\/kidneydiseaseclinic.net\/blog\/wp-json\/wp\/v2\/posts\/1087","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/kidneydiseaseclinic.net\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/kidneydiseaseclinic.net\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/blog\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/blog\/wp-json\/wp\/v2\/comments?post=1087"}],"version-history":[{"count":1,"href":"https:\/\/kidneydiseaseclinic.net\/blog\/wp-json\/wp\/v2\/posts\/1087\/revisions"}],"predecessor-version":[{"id":1088,"href":"https:\/\/kidneydiseaseclinic.net\/blog\/wp-json\/wp\/v2\/posts\/1087\/revisions\/1088"}],"wp:attachment":[{"href":"https:\/\/kidneydiseaseclinic.net\/blog\/wp-json\/wp\/v2\/media?parent=1087"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/blog\/wp-json\/wp\/v2\/categories?post=1087"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/blog\/wp-json\/wp\/v2\/tags?post=1087"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}