Repeated use of local corticosteroids presents several hazards: herpes simplex (dendritic) and fungal keratitis, openangle glaucoma, and cataract formation Furthermore, perforation of the cornea may occur when corticosteroids are used for herpes simplex keratitis Topical nonsteroidal anti-inflammatory agents can be a good alternative The potential for causing or exacerbating systemic hypertension, diabetes mellitus, gastritis, osteoporosis, or glaucoma must always be borne in mind when systemic corticosteroids are prescribed, such as for uveitis or giant cell arteritis